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Details on Person Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM

Class:Id	Reaction:209112
_displayName	Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM
_doRelease	TRUE
_timestamp	2018-03-09 00:14:29
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
catalystActivity	[CatalystActivity:208950] protein serine/threonine phosphatase activity of PP2A [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:210813] /figures/CDrosWing18.jpg
inferredFrom	[Reaction:209091] Human beta-catenin is dephosphorylated by PP2A [Homo sapiens] [Reaction:209089] Human APC is dephosphorylated by PP2A [Homo sapiens] [Reaction:209096] Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin [Mus musculus]
input	[Complex:206952] WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] [Drosophila melanogaster]
modified	[InstanceEdit:205613] Williams, MG, 2006-07-20 14:47:06 [InstanceEdit:208731] Williams, MG, 2006-09-22 14:12:19 [InstanceEdit:206331] Williams, MG, 2006-10-24 13:03:16 [InstanceEdit:210817] Williams, MG, 2008-01-16 16:52:43 [InstanceEdit:350520] Williams, MG, 2008-05-19 14:28:13 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM
output	[Complex:206993] WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:205774] ARM [cytosol] [Drosophila melanogaster] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:209120] Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR [Drosophila melanogaster] [Reaction:209135] GISH further phosphorylates ARR in the receptor complex [Drosophila melanogaster] [Reaction:209109] Further phosphorylation of ARM by SGG [Drosophila melanogaster] [Reaction:209081] Disassembly of the destabilised 'destruction complex' [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8897626] R-DME-209112.4
summation	[Summation:206513] The binding of Dishevelled (DSH) to Axin (AXN) in the 'destr...
(hasEvent)	[Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM [Drosophila melanogaster]
(precedingEvent)	[BlackBoxEvent:209075] Destabilisation and degradation of AXN in the 'destruction complex' [Drosophila melanogaster] [Reaction:209097] ARM binds to APC and AXN in the 'destruction complex' [Drosophila melanogaster] [Reaction:209371] LGS binds to ARM [Drosophila melanogaster]
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