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Details on Person Human beta-TrCP binds to phosphorylated beta-catenin to form the 'destruction complex'

Class:Id	Reaction:209101
_displayName	Human beta-TrCP binds to phosphorylated beta-catenin to form the 'destruction complex'
_doRelease	FALSE
_timestamp	2017-08-22 01:29:23
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205655] Williams, MG, 2006-10-24 12:52:33
figure	[Figure:208723] /figures/BDrosWing09a.jpg
input	[Complex:206859] Phospho (4 sites) beta-catenin:Phospho (3 sites) Axin1:Phospho (6 sites) APC:PP2A:CKIalpha:CKIepsilon:GSK3beta [cytosol] [Homo sapiens] [Complex:206748] BTRC:CUL1:RBX1:SKP1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:196256] Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase [LiteratureReference:196245] The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro [LiteratureReference:174111] The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin [LiteratureReference:208209] The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
modified	[InstanceEdit:209093] Williams, MG, 2007-07-12 09:35:45 [InstanceEdit:350518] Williams, MG, 2008-05-19 14:22:57 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9017535] Matthews, Lisa, 2017-08-22
name	Human beta-TrCP binds to phosphorylated beta-catenin to form the 'destruction complex'
output	[Complex:206632] beta-TrCP:Skp1:Cul1:Rbx1:E2:phospho (4 sites) beta-catenin:phospho (3 sites) Axin1:phospho (6 sites) APC:PP2A:CKIalpha:CKIepsilon:GSK3beta [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8895409] R-HSA-209101.1
(hasEvent)	[Pathway:209389] Wingless pathway - Inferred Events
(inferredFrom)	[Reaction:209102] SLMB binds to phosphorylated ARM to form the 'destruction complex' [Drosophila melanogaster]
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