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Details on Person Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin

Class:Id	Reaction:209096
_displayName	Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin
_doRelease	TRUE
_timestamp	2016-11-10 00:55:25
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
catalystActivity	[CatalystActivity:208859] protein serine/threonine phosphatase activity of PP2A [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205655] Williams, MG, 2006-10-24 12:52:33
figure	[Figure:208409] /figures/BDrosWing18c.jpg
input	[Complex:206963] beta-catenin:phospho (3 sites) Axin1 [cytosol] [Mus musculus]
literatureReference	[LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208242] A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression [LiteratureReference:3640789] Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
modified	[InstanceEdit:209093] Williams, MG, 2007-07-12 09:35:45 [InstanceEdit:350523] Williams, MG, 2008-05-19 14:31:02 [InstanceEdit:386960] Williams, MG, 2008-11-27 15:03:15 [InstanceEdit:5140047] Rothfels, K, 2013-11-15 [InstanceEdit:5146683] Rothfels, K, 2013-11-18 [InstanceEdit:5251604] Rothfels, K, 2014-02-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin
output	[EntityWithAccessionedSequence:205727] Axin1 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:206225] beta-catenin [cytosol] [Mus musculus] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2006-08-02
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:5644730] R-MMU-209096.3
summation	[Summation:3640830] AXIN is believed to be dephosphorylated upon WNT pathway sti...
(hasEvent)	[Pathway:209389] Wingless pathway - Inferred Events
(inferredFrom)	[Reaction:209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM [Drosophila melanogaster] [BlackBoxEvent:3601585] PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780649] Update Tracker - [Reaction:209096] Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin - v62:[modifyText]
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