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Details on Person Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'

Class:Id	Reaction:209094
_displayName	Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'
_doRelease	TRUE
_timestamp	2018-03-09 00:13:26
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
catalystActivity	[CatalystActivity:208868] ubiquitin-protein transferase activity of SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:206331] Williams, MG, 2006-10-24 13:03:16
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:208613] /figures/BDrosWing10.jpg
inferredFrom	[Reaction:209128] Dissociation of free ubiquitinated and phosphorylated human beta-catenin from beta-TrCP and the 'destruction complex' [Homo sapiens]
input	[Complex:207002] SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] [Drosophila melanogaster] [DefinedSet:206204] UBI-P63E [cytosol] [Drosophila melanogaster]
modified	[InstanceEdit:350489] Williams, MG, 2008-05-19 14:08:07 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'
output	[Complex:206602] Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] [Drosophila melanogaster] [Complex:206788] SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] [Drosophila melanogaster] [Complex:206991] UBI-P63E:Phospho (4 sites) ARM [cytosol] [Drosophila melanogaster]
precedingEvent	[Reaction:209102] SLMB binds to phosphorylated ARM to form the 'destruction complex' [Drosophila melanogaster] [Reaction:209109] Further phosphorylation of ARM by SGG [Drosophila melanogaster] [Reaction:209094] Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8928627] R-DME-209094.4
summation	[Summation:206452] The bound and phosphorylated Armadillo (ARM) is ubiquitated ...
(hasEvent)	[Pathway:209461] Ubiquitination and degradation of phosphorylated ARM [Drosophila melanogaster]
(precedingEvent)	[Reaction:209097] ARM binds to APC and AXN in the 'destruction complex' [Drosophila melanogaster] [Reaction:209102] SLMB binds to phosphorylated ARM to form the 'destruction complex' [Drosophila melanogaster] [BlackBoxEvent:209129] Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex [Drosophila melanogaster]
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