Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Disassembly of the destabilised 'destruction complex'

Class:Id	Reaction:209081
_displayName	Disassembly of the destabilised 'destruction complex'
_doRelease	TRUE
_timestamp	2018-03-09 00:13:22
authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:210814] /figures/CDrosWing20.jpg
input	[Complex:206837] WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208103] Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity [LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:208273] Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
modified	[InstanceEdit:205613] Williams, MG, 2006-07-20 14:47:06 [InstanceEdit:208731] Williams, MG, 2006-09-22 14:12:19 [InstanceEdit:206331] Williams, MG, 2006-10-24 13:03:16 [InstanceEdit:209522] Schmidt, EE, 2007-06-04 09:24:47 [InstanceEdit:209093] Williams, MG, 2007-07-12 09:35:45 [InstanceEdit:210817] Williams, MG, 2008-01-16 16:52:43 [InstanceEdit:350489] Williams, MG, 2008-05-19 14:08:07 [InstanceEdit:386957] Williams, MG, 2008-11-27 14:37:44 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024533] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Disassembly of the destabilised 'destruction complex'
output	[DefinedSet:206581] APC [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205729] DCO [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:206210] CKIalpha [cytosol] [Drosophila melanogaster] [Complex:206938] PP2A [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205749] DSH [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:205716] SGG [cytosol] [Drosophila melanogaster] [Complex:206613] WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] [Drosophila melanogaster]
precedingEvent	[BlackBoxEvent:209075] Destabilisation and degradation of AXN in the 'destruction complex' [Drosophila melanogaster] [Reaction:209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8898839] R-DME-209081.4
summation	[Summation:206333] The destabilised 'destruction complex' disassembles into the...
(hasEvent)	[Pathway:209440] Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM [Drosophila melanogaster]
(precedingEvent)	[Reaction:209120] Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR [Drosophila melanogaster] [Reaction:209133] Formation of the 'destruction complex' [Drosophila melanogaster]
[Change default viewing format]

No pathways have been reviewed or authored by Disassembly of the destabilised 'destruction complex' (209081)