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Details on Person Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex

Class:Id	BlackBoxEvent:209061
_displayName	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
_doRelease	TRUE
_timestamp	2017-10-05 18:25:24
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
edited	[InstanceEdit:744685] Jupe, S, 2010-05-17
figure	[Figure:208577] /figures/DrosTollImdA20.jpg
input	[Complex:206877] NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:208148] Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha [LiteratureReference:208176] Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP [LiteratureReference:208375] Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP [LiteratureReference:208290] Identification of the receptor component of the IkappaBalpha-ubiquitin ligase [LiteratureReference:208326] Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway [LiteratureReference:5607191] SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4
modified	[InstanceEdit:350540] Williams, MG, 2008-05-19 14:43:09 [InstanceEdit:386964] Williams, MG, 2008-11-27 15:41:07 [InstanceEdit:451601] Jupe, S, 2010-01-06 [InstanceEdit:451610] Jupe, S, 2010-01-06 [InstanceEdit:744685] Jupe, S, 2010-05-17 [InstanceEdit:744687] Jupe, S, 2010-05-17 [InstanceEdit:772535] Jupe, S, 2010-05-21 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8951416] Jupe, Steve, 2016-12-02 [InstanceEdit:8979573] Jupe, Steve, 2017-02-27 [InstanceEdit:9020703] Jupe, Steve, 2017-09-11 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
output	[Complex:194043] NFKB1(1-433):RELA [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
releaseDate	2017-09-12
reviewed	[InstanceEdit:744680] Pinteaux, E, 2010-05-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8925784] R-HSA-209061.3
summation	[Summation:8979574] Ubiquitinated IKBA is degraded by the proteasome complex.
(hasEvent)	[Pathway:9020702] Interleukin-1 signaling [Homo sapiens]
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