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Details on Person TLD cleaves SOG and the DPP/SCW dimer complex dissociates

Class:Id	Reaction:209029
_displayName	TLD cleaves SOG and the DPP/SCW dimer complex dissociates
_doRelease	FALSE
_timestamp	2016-07-15 23:49:21
authored	[InstanceEdit:386951] Williams, MG, 2007-03-22 16:49:12
catalystActivity	[CatalystActivity:208948] metalloendopeptidase activity of TLD [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:205608] Williams, MG, 2007-03-27 14:11:11
figure	[Figure:870743] /figures/DrosBMPActB04.jpg
input	[Complex:206932] SOG:DPP/SCW dimer:TSG [extracellular region] [Drosophila melanogaster]
literatureReference	[LiteratureReference:208139] Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo [LiteratureReference:208265] Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo [LiteratureReference:208048] Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins [LiteratureReference:208146] Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV [LiteratureReference:208169] Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity [LiteratureReference:208261] Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning
modified	[InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38 [InstanceEdit:870763] Williams, MG, 2010-06-08 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	TLD cleaves SOG and the DPP/SCW dimer complex dissociates
output	[DefinedSet:870596] DPP/SCW dimer [extracellular region] [Drosophila melanogaster] [EntityWithAccessionedSequence:206083] SOG [extracellular region] [Drosophila melanogaster] [EntityWithAccessionedSequence:205897] TSG [extracellular region] [Drosophila melanogaster]
precedingEvent	[Reaction:209035] DPP/SCW dimers bind to SOG and TSG [Drosophila melanogaster] [Reaction:209003] Mature BMP/Act dimers transport from the trans-golgi to the extracellular space [Drosophila melanogaster] [Reaction:209029] TLD cleaves SOG and the DPP/SCW dimer complex dissociates [Drosophila melanogaster]
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8892647] R-DME-209029.1
summation	[Summation:870750] The metalloproteinase Tolloid (TLD) cleaves Short gastrulati...
(hasEvent)	[Pathway:209466] Transport of ligand dimers in the extracellular region [Drosophila melanogaster]
(precedingEvent)	[Reaction:208981] DPP:SCW dimer binds to TKV:SAX dimer [Drosophila melanogaster] [Reaction:209010] SCW and GBB dimers bind to SAX dimer [Drosophila melanogaster] [Reaction:209035] DPP/SCW dimers bind to SOG and TSG [Drosophila melanogaster] [Reaction:209043] DPP and GBB dimers bind to TKV dimer [Drosophila melanogaster]
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