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Details on Person Phosphorylated SMAD2 dissociates from SARA and Phospho TGFBR1 dimer

Class:Id	Reaction:209015
_displayName	Phosphorylated SMAD2 dissociates from SARA and Phospho TGFBR1 dimer
_doRelease	FALSE
_timestamp	2016-07-15 23:49:33
authored	[InstanceEdit:386951] Williams, MG, 2007-03-22 16:49:12
compartment	[Compartment:17941] early endosome
created	[InstanceEdit:205608] Williams, MG, 2007-03-27 14:11:11
figure	[Figure:870698] /figures/DrosBMPActB59.jpg
input	[Complex:206745] TGFBR2 dimer:TGFB1 dimer:Phospho TGFBR1 dimer:Phospho SMAD2:SARA [early endosome membrane] [Homo sapiens]
literatureReference	[LiteratureReference:208162] Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
modified	[InstanceEdit:350520] Williams, MG, 2008-05-19 14:28:13 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:870696] Williams, MG, 2010-06-08 [InstanceEdit:3009364] Jassal, B, 2013-02-05 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Phosphorylated SMAD2 dissociates from SARA and Phospho TGFBR1 dimer
output	[Complex:206879] TGFBR2 dimer:TGFB1 dimer:Phospho TGFBR1 dimer [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:206180] ZFYVE9-1 [early endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:3009186] p-S465,S467-SMAD2 [cytosol] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8897941] R-HSA-209015.1
summation	[Summation:870704] In humans, the phosphorylated R-Smad, SMAD2, now has a confo...
(hasEvent)	[Pathway:209460] BMP/Activin pathway - Inferred Events
(inferredFrom)	[Reaction:209023] Phosphorylated MAD/SMOX dissociates from SARA and the BMP/Act ligand:receptors complex [Drosophila melanogaster]
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