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Details on Person IDUA hydrolyses Heparan sulfate chain(6)

Class:Id	Reaction:2090037
_displayName	IDUA hydrolyses Heparan sulfate chain(6)
_doRelease	TRUE
_timestamp	2018-01-29 15:32:26
authored	[InstanceEdit:2090024] Jassal, B, 2012-02-06
catalystActivity	[CatalystActivity:1678683] L-iduronidase activity of IDUA [lysosomal lumen]
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2090024] Jassal, B, 2012-02-06
edited	[InstanceEdit:2090024] Jassal, B, 2012-02-06
input	[SimpleEntity:1605715] H2O [lysosomal lumen] [SimpleEntity:2090055] IdoA-GlcNS3S- group [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:1678628] Human alpha-L-iduronidase: cDNA isolation and expression [LiteratureReference:1678646] Mucopolysaccharidosis type I: characterization of novel mutations affecting alpha-L-iduronidase activity
modified	[InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2318608] Jassal, B, 2012-06-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2429636] Jupe, S, 2012-08-09 [InstanceEdit:2457601] Jassal, B, 2012-08-24 [InstanceEdit:9036076] Jassal, Bijay, 2018-01-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IDUA hydrolyses Heparan sulfate chain(6) Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
output	[SimpleEntity:1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:2090070] GlcNS3S- group [lysosomal lumen]
precedingEvent	[Reaction:1678650] IDS hydrolyses Heparan sulfate chain(5) [Homo sapiens] [Reaction:1678742] NAGLU hydrolyses Heparan sulfate chain(4) [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295037] R-HSA-2090037.3
summation	[Summation:1678630] The lysosomal enzyme alpha-L-iduronidase (IDUA) cleaves the ...
(hasEvent)	[Pathway:2024096] HS-GAG degradation [Homo sapiens]
(normalReaction)	[FailedReaction:2206299] Defective IDUA does not hydrolyse Heparan sulfate chain(6) [Homo sapiens]
(precedingEvent)	[Reaction:2090043] SGSH hydrolyses Heparan sulfate chain(7) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788383] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v42:[modifyText] [_UpdateTracker:9953735] Update Tracker - [Reaction:2090037] IDUA hydrolyses Heparan sulfate chain(6) - v93:[modifyText]
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No pathways have been reviewed or authored by IDUA hydrolyses Heparan sulfate chain(6) (2090037)