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Details on Person TGFBR2 phosphorylates TGFBR1 in the TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer complex

Class:Id	Reaction:208968
_displayName	TGFBR2 phosphorylates TGFBR1 in the TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer complex
_doRelease	FALSE
_timestamp	2016-07-15 23:50:51
authored	[InstanceEdit:386951] Williams, MG, 2007-03-22 16:49:12
catalystActivity	[CatalystActivity:208935] protein serine/threonine kinase activity of TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205608] Williams, MG, 2007-03-27 14:11:11
figure	[Figure:870757] /figures/DrosBMPActB56.jpg
input	[Complex:206874] TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:175965] Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses [LiteratureReference:208059] GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex [LiteratureReference:175963] Mechanism of activation of the TGF-beta receptor
modified	[InstanceEdit:350517] Williams, MG, 2008-05-19 14:22:08 [InstanceEdit:386959] Williams, MG, 2008-11-27 14:56:57 [InstanceEdit:870763] Williams, MG, 2010-06-08 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	TGFBR2 phosphorylates TGFBR1 in the TGFBR2 dimer:TGFB1 dimer:TGFBR1 dimer complex
output	[Complex:206804] TGFBR2 dimer:TGFB1 dimer:Phospho TGFBR1 dimer [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8930462] R-HSA-208968.1
summation	[Summation:870724] In humans, the serine/threonine kinase domain in the cytopla...
(hasEvent)	[Pathway:209460] BMP/Activin pathway - Inferred Events
(inferredFrom)	[Reaction:208961] SAX is phosphorylated by PUT and WIT [Drosophila melanogaster] [Reaction:208984] TKV is phosphorylated by PUT and WIT [Drosophila melanogaster] [Reaction:209011] TKV:SAX is phosphorylated by PUT [Drosophila melanogaster] [Reaction:209122] BABO is phosphorylated by PUT and WIT [Drosophila melanogaster]
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