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Details on Person Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

Class:IdLiteratureReference:208375
_displayNameSignal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
_timestamp2007-12-18 11:51:17
author[Person:207994] Spencer, E
[Person:207546] Jiang, J
[Person:202464] Chen, ZJ
created[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
journalGenes Dev
pages284-94
pubMedIdentifier9990853
titleSignal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
volume13
year1999
(literatureReference)[BlackBoxEvent:209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex [Homo sapiens]
[Reaction:209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex [Homo sapiens]
[Reaction:209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex [Homo sapiens]
[BlackBoxEvent:214871] Phosphorylated CACT is degraded in the cytosol [Drosophila melanogaster]
[BlackBoxEvent:5607728] beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex [Homo sapiens]
[Reaction:9974817] SCF-Beta-TrCP complex binding to NFKB p50:p65:phospho-IKBA complex is negatively regulated by RV-A NSP1 [Homo sapiens]
[Summation:5607608] Following ubiquitination NF-kappa-B inhibitor alpha (NFKBIA ...
[Summation:9974815]

Human beta-TrCP forms part of the SCF E3 ubiquitin ligase...
[CatalystActivityReference:9643297] ubiquitin-protein transferase activity of SCF-beta-TRCP [cytosol] Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

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