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Details on Person Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Class:IdLiteratureReference:208290
_displayNameIdentification of the receptor component of the IkappaBalpha-ubiquitin ligase
_timestamp2007-12-18 11:50:14
author[Person:207984] Yaron, A
[Person:196260] Hatzubai, A
[Person:207265] Davis, M
[Person:207339] Lavon, I
[Person:196279] Amit, S
[Person:207572] Manning, AM
[Person:196270] Andersen, JS
[Person:72121] Mann, M
[Person:207959] Mercurio, F
[Person:196259] Ben-Neriah, Y
created[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
journalNature
pages590-4
pubMedIdentifier9859996
titleIdentification of the receptor component of the IkappaBalpha-ubiquitin ligase
volume396
year1998
(literatureReference)[BlackBoxEvent:209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex [Homo sapiens]
[Reaction:209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex [Homo sapiens]
[Reaction:209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex [Homo sapiens]
[Reaction:1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB [Homo sapiens]
[BlackBoxEvent:1168643] SCF-beta-TrCP ubiquitinylates IkB [Homo sapiens]
[Reaction:9974817] SCF-Beta-TrCP complex binding to NFKB p50:p65:phospho-IKBA complex is negatively regulated by RV-A NSP1 [Homo sapiens]
[Summation:9974815]

Human beta-TrCP forms part of the SCF E3 ubiquitin ligase...

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