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Details on Person TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
| Class:Id | LiteratureReference:208287 |
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| _displayName | TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway |
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| _timestamp | 2007-12-18 11:50:12 |
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| author | [Person:207743] Takaesu, G
[Person:207500] Kishida, S
[Person:207479] Hiyama, A
[Person:169926] Yamaguchi, K
[Person:169983] Shibuya, H
[Person:170016] Irie, K
[Person:170008] Ninomiya-Tsuji, J
[Person:158711] Matsumoto, K |
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| created | [InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19 |
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| journal | Mol Cell |
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| pages | 649-58 |
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| pubMedIdentifier | 10882101 |
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| title | TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway |
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| volume | 5 |
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| year | 2000 |
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| (literatureReference) | [DefinedSet:446874] TAB2,TAB3 [cytosol] [Homo sapiens]
[DefinedSet:975101] TAB2/3 [endosome membrane] [Homo sapiens]
[Reaction:209236] Human TAB2 binds to ubiquitinated TRAF6:Ubc13:UEV1a E3 ligase complex and activates TAK1 kinase [Homo sapiens]
[Reaction:446870] Polyubiquitinated TRAF6 binds the TAK1 complex [Homo sapiens]
[Reaction:936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
[Reaction:936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex [Homo sapiens]
[Reaction:975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation [Homo sapiens]
[Reaction:2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 [Homo sapiens]
[Reaction:5607759] TRIKA2 binds K63polyUb-TRAF6 oligomer [Homo sapiens]
[Summation:5607596] K-63 linked polyubiquitin (pUb) chain on TRAF6 provides a sc... |
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