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Details on Person Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP

Class:IdLiteratureReference:208176
_displayNameInducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP
_timestamp2007-12-18 11:48:50
author[Person:207170] Kroll, M
[Person:180541] Margottin, F
[Person:207246] Kohl, Andreas
[Person:207681] Renard, P
[Person:180587] Durand, H
[Person:207274] Concordet, JP
[Person:207182] Bachelerie, F
[Person:207446] Arenzana-Seisdedos, F
[Person:180558] Benarous, Richard
created[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
journalJ Biol Chem
pages7941-5
pubMedIdentifier10075690
titleInducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP
volume274
year1999
(literatureReference)[Summation:9974815]

Human beta-TrCP forms part of the SCF E3 ubiquitin ligase...
[BlackBoxEvent:209061] Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex [Homo sapiens]
[Reaction:209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex [Homo sapiens]
[Reaction:9974817] SCF-Beta-TrCP complex binding to NFKB p50:p65:phospho-IKBA complex is negatively regulated by RV-A NSP1 [Homo sapiens]

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