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Details on Person CD19 Signalosome [plasma membrane]

Class:Id	Complex:2076233
_displayName	CD19 Signalosome [plasma membrane]
_timestamp	2012-03-01 11:44:17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2076259] May, B, 2012-01-27
hasComponent	[EntityWithAccessionedSequence:2076270] p-6Y-CD19 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1045153] VAV1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:202993] GRB2-1 [plasma membrane] [Homo sapiens] [Complex:1045152] PIK3CD:PIK3R1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:392274] PIK3CD [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:198365] PIK3R1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2076268] Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines [LiteratureReference:2076271] Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric [LiteratureReference:2076242] Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors
name	CD19 Signalosome
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2159033] R-HSA-2076233.1
(hasMember)	[DefinedSet:2316432] Activator:PI3K [plasma membrane] [Homo sapiens]
(output)	[Reaction:9606887] p-CD19:VAV binds PI3K and GRB2 [Homo sapiens]
(physicalEntity)	[CatalystActivity:2076231] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD19 Signalosome [plasma membrane]
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No pathways have been reviewed or authored by CD19 Signalosome [plasma membrane] (2076233)