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Details on Person BTRC:CUL1:RBX1:SKP1 [cytosol]

Class:Id	Complex:206748
_displayName	BTRC:CUL1:RBX1:SKP1 [cytosol]
_timestamp	2017-07-13 16:40:09
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205655] Williams, MG, 2006-10-24 12:52:33
hasComponent	[EntityWithAccessionedSequence:174237] BTRC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174150] SKP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174230] CUL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180582] RBX1 [cytosol] [Homo sapiens]
modified	[InstanceEdit:206989] Williams, MG, 2007-07-12 09:59:29 [InstanceEdit:209587] Jassal, B, 2007-12-19 11:00:26 [InstanceEdit:258120] Schmidt, EE, 2008-03-27 09:04:40 [InstanceEdit:451618] Jupe, S, 2010-01-07 [InstanceEdit:9012434] Duenas, Corina, 2017-07-13
name	BTRC:CUL1:RBX1:SKP1 SCF beta-TrCP complex beta-TrCP:Skp1:Cul1:Rbx1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1112264] R-HSA-206748.2
(activeUnit)	[CatalystActivity:9938995] ubiquitin-protein transferase activity of p-S184,T180-CD274:BTRC E3 complex [cytosol]
(hasComponent)	[Complex:206632] beta-TrCP:Skp1:Cul1:Rbx1:E2:phospho (4 sites) beta-catenin:phospho (3 sites) Axin1:phospho (6 sites) APC:PP2A:CKIalpha:CKIepsilon:GSK3beta [cytosol] [Homo sapiens] [Complex:206891] NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] [Homo sapiens] [Complex:451614] SCF betaTrCP complex:p-NFKB p105 [cytosol] [Homo sapiens] [Complex:1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] [Homo sapiens] [Complex:2130280] RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] [Homo sapiens] [Complex:9012428] BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] [Homo sapiens] [Complex:9666608] RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated CTNNB1 ubiquitination mutants [cytosol] [Homo sapiens] [Complex:9750235] K27polyUb-384-NLRP3:BTRC:CUL1:RBX1:SKP1 [cytosol] [Homo sapiens] [Complex:9929358] p-S184,T180-CD274:BTRC E3 complex [cytosol] [Homo sapiens] [Complex:9974793] CRL3-NSP1:SCF-BTRC [cytosol] [Homo sapiens]
(input)	[Reaction:209101] Human beta-TrCP binds to phosphorylated beta-catenin to form the 'destruction complex' [Homo sapiens] [Reaction:209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex [Homo sapiens] [Reaction:1370500] PRLR binds SCF beta-TrCP complex [Homo sapiens] [Reaction:2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex [Homo sapiens] [BlackBoxEvent:9748776] CRL1 (BTRC) polyubiquitinates NLRP3 at K384 [Homo sapiens] [Reaction:9929357] p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex [Homo sapiens] [Reaction:9974798] CRL3-NSP1 complex binds BTRC [Homo sapiens] [Reaction:9974817] SCF-Beta-TrCP complex binding to NFKB p50:p65:phospho-IKBA complex is negatively regulated by RV-A NSP1 [Homo sapiens]
(output)	[Reaction:209128] Dissociation of free ubiquitinated and phosphorylated human beta-catenin from beta-TrCP and the 'destruction complex' [Homo sapiens] [Reaction:209230] Dissociation of free ubiquitinated and phosphorylated human Gli3 ftom beta-Trcp [Homo sapiens] [BlackBoxEvent:1170539] Prolactin receptor is internalized [Homo sapiens] [BlackBoxEvent:2130282] Degradation of ubiquitinated beta catenin by the proteasome [Homo sapiens] [BlackBoxEvent:9012405] BTRC:CUL1:RBX1:SKP1 dissociates from BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub complex [Homo sapiens] [Reaction:9929352] Ubiquitinated CD274 is degraded by the 26S proteasome [Homo sapiens]
(physicalEntity)	[CatalystActivity:208937] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
(updatedInstance)	[_UpdateTracker:9897476] Update Tracker - [Complex:206748] BTRC:CUL1:RBX1:SKP1 [cytosol] - v62:[addName]
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No pathways have been reviewed or authored by BTRC:CUL1:RBX1:SKP1 [cytosol] (206748)