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Details on Person Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(...
| Class:Id | Summation:2066737 |
|---|---|
| _displayName | Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(... |
| _timestamp | 2012-01-27 16:19:50 |
| created | [InstanceEdit:2066728] Garapati, P V, 2012-01-25 |
| literatureReference | [LiteratureReference:2066732] Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid |
| modified | [InstanceEdit:2076702] Jupe, S, 2012-01-27 |
| text | Retroconversion of C24:6(n-3) to docosahexaenoic acid (22:6(n-3) involves the initial oxidation of tetracosahexaenoyl-CoA to an intermediate 1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA (delta2-THA-CoA). This step is catalysed by the peroxisomal enzyme Straight-chain acyl-CoA oxidase (SCOX) (Ferdinandusse et al. 2001). |
| (summation) | [Reaction:2066787] Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA [Homo sapiens] |
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