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Details on Person FGFR2b mutant-binding FGFs [extracellular region]

Class:Id	DefinedSet:2065925
_displayName	FGFR2b mutant-binding FGFs [extracellular region]
_timestamp	2012-05-31 10:04:37
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2065926] Rothfels, K, 2012-01-24
hasMember	[EntityWithAccessionedSequence:189898] FGF2(143-288) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189881] FGF6 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189870] FGF9 [extracellular region] [Homo sapiens] [DefinedSet:189967] FGFR2b-binding FGFs [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189856] FGF1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189886] FGF3 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189884] FGF7 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189869] FGF10 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:189877] FGF22 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:2012014] Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome [LiteratureReference:2029802] Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
name	FGFR2b mutant-binding FGFs
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2296022] R-HSA-2065925.1
(hasComponent)	[Complex:2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] [Homo sapiens] [Complex:2065931] Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] [Homo sapiens] [Complex:2077406] FGFR2b mutant-binding FGFs:FP-1039 [extracellular region] [Homo sapiens]
(input)	[Reaction:2033474] FGFR2b mutants bind an expanded range of ligands [Homo sapiens] [Reaction:2077421] FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer [Homo sapiens]
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No pathways have been reviewed or authored by FGFR2b mutant-binding FGFs [extracellular region] (2065925)