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Details on Person Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino...
| Class:Id | Summation:2065403 |
|---|---|
| _displayName | Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino... |
| _timestamp | 2012-08-06 16:37:05 |
| created | [InstanceEdit:2065361] May, B, 2012-01-21 |
| modified | [InstanceEdit:2426574] May, B, 2012-08-06 |
| text | Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino acid residues from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Wei et al. 1991). This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). ACE is secreted ("shed") from membranes of endothelial cells by cleavage in the C-terminal region that removes the membrane anchor. |
| (summation) | [Reaction:2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] |
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