Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))

Class:Id	Reaction:2065357
_displayName	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))
_doRelease	TRUE
_timestamp	2025-04-06 15:54:06
authored	[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity	[CatalystActivity:2065406] aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643694] aspartic-type endopeptidase activity of Prorenin-Prorenin Receptor [plasma membrane] Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2065361] May, B, 2012-01-21
edited	[InstanceEdit:1998760] May, B, 2011-11-19
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
input	[EntityWithAccessionedSequence:1998759] AGT [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:2022186] Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin [LiteratureReference:2065392] Aliskiren displays long-lasting interactions with human renin [LiteratureReference:2065380] Structure-based design of aliskiren, a novel orally effective renin inhibitor
modified	[InstanceEdit:2426577] May, B, 2012-08-06 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9944607] May, Bruce, 2025-04-06
name	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) Prorenin Bound to Renin Receptor Hydrolyzes Angiotensinogen to Yield Angiotensin I
output	[EntityWithAccessionedSequence:2022346] AGT(25-34) [extracellular region] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [Reaction:2022382] Renin binds the Renin Receptor [Homo sapiens]
regulatedBy	[NegativeRegulation:2065428] Negative regulation by 'aliskiren [extracellular region]'
regulationReference	[RegulationReference:9642602] Negative regulation by 'aliskiren [extracellular region]' Aliskiren displays long-lasting interactions with human renin
releaseDate	2012-09-18
reviewed	[InstanceEdit:2426575] Joseph, J, 2012-08-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464852] R-HSA-2065357.5
summation	[Summation:2065370] The binding of prorenin to the (pro)renin receptor activates...
(hasEvent)	[Pathway:2022377] Metabolism of Angiotensinogen to Angiotensins [Homo sapiens]
(precedingEvent)	[Reaction:2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) [Homo sapiens] [Reaction:2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) [Homo sapiens] [Reaction:2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens] [Reaction:2028294] Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) [Homo sapiens] [Reaction:2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) (2065357)