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Details on Person Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Class:Id	Reaction:2065355
_displayName	Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
_doRelease	TRUE
_timestamp	2025-04-06 15:54:35
authored	[InstanceEdit:1998760] May, B, 2011-11-19
catalystActivity	[CatalystActivity:2065398] metallodipeptidase activity of ACE(30-1232):Zn2+ [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643114] metallodipeptidase activity of ACE(30-1232):Zn2+ [extracellular region] Angiotensin I-converting enzyme mutation (Trp1197Stop) causes a dramatic increase in blood ACE
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2065361] May, B, 2012-01-21
edited	[InstanceEdit:1998760] May, B, 2011-11-19
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
input	[EntityWithAccessionedSequence:2022346] AGT(25-34) [extracellular region] [Homo sapiens] [SimpleEntity:109276] H2O [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:2065409] Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes [LiteratureReference:2065402] The two homologous domains of human angiotensin I-converting enzyme are both catalytically active [LiteratureReference:2065394] Purification of angiotensin-converting enzyme from human intestine [LiteratureReference:2065382] Purification of human lung angiotensin-converting enzyme [LiteratureReference:2065372] Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine [LiteratureReference:2065397] Purification and characterization of human converting enzyme (kininase II) [LiteratureReference:2065388] Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat [LiteratureReference:2028297] Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
modified	[InstanceEdit:2426577] May, B, 2012-08-06 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9614946] Jassal, Bijay, 2018-07-30 [InstanceEdit:9615218] Jassal, Bijay, 2018-07-31 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9695989] Jassal, Bijay, 2020-07-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856115] May, Bruce, 2023-12-11 [InstanceEdit:9944607] May, Bruce, 2025-04-06
name	Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
output	[EntityWithAccessionedSequence:374187] AGT(25-32) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2022382] Renin binds the Renin Receptor [Homo sapiens] [Reaction:2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) [Homo sapiens] [BlackBoxEvent:1989774] Expression of AGT [Homo sapiens] [Reaction:2022382] Renin binds the Renin Receptor [Homo sapiens]
regulatedBy	[PositiveRegulation:2065425] Positive regulation by 'Cl- [extracellular region]' [NegativeRegulation:9614930] Negative regulation by 'ACEIs:ACE(30-1232) [extracellular region]'
releaseDate	2012-09-18
reviewed	[InstanceEdit:2426575] Joseph, J, 2012-08-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464837] R-HSA-2065355.9
summation	[Summation:2065403] Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino...
(hasEvent)	[Pathway:2022377] Metabolism of Angiotensinogen to Angiotensins [Homo sapiens]
(precedingEvent)	[Reaction:374173] AGT(25-32) binds to AGTR1 [Homo sapiens] [Reaction:2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) [Homo sapiens] [Reaction:2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) [Homo sapiens] [Reaction:9615348] AGT(25-32) binds to AGTR2 [Homo sapiens] [BlackBoxEvent:9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779061] Update Tracker - [Reaction:2065355] Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) - v66:[add_removeRegulator]
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