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Details on Person Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (hu...
| Class:Id | Summation:2065283 |
|---|---|
| _displayName | Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (hu... |
| _timestamp | 2018-04-18 14:11:08 |
| created | [InstanceEdit:2065284] Orlic-Milacic, M, 2012-01-20 |
| literatureReference | [LiteratureReference:186471] Notch signalling controls pancreatic cell differentiation [LiteratureReference:186526] Control of endodermal endocrine development by Hes-1 |
| modified | [InstanceEdit:2085528] Orlic-Milacic, M, 2012-02-03 [InstanceEdit:4396368] Orlic-Milacic, M, 2013-08-22 [InstanceEdit:9606098] Orlic-Milacic, Marija, 2018-04-18 |
| text | Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (human cervical carcinoma cell line) associates with human RBPJ and, after binding to a recombinant mouse Hes1 promoter, activates transcription of a reporter gene (Jarriault et al. 1995). The deletion of RBP-J results in increased differentiation of Ngn3 cells, most likely because of decreased expression of Hes1 and other Notch targets (Apelqvist et al. 1999, Jensen et al. 2000). |
| (summation) | [BlackBoxEvent:2065278] mNICD1 stimulates Hes1 transcription [Homo sapiens] |
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No pathways have been reviewed or authored by Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (hu... (2065283)
