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Details on Person CDK8 phosphorylates xNICD1

Class:IdReaction:2065178
_displayNameCDK8 phosphorylates xNICD1
_doReleaseTRUE
_timestamp2012-03-01 11:21:26
authored[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity[CatalystActivity:2065175] cyclin-dependent protein serine/threonine kinase activity of xNOTCH1 Chimeric Coactivator Complex:CDK8:CCNC [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2065177] Orlic-Milacic, M, 2012-01-20
edited[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10
[InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
input[Complex:2064914] xNOTCH1 Chimeric Coactivator Complex:CDK8:CCNC [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
isChimericTRUE
literatureReference[LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
modified[InstanceEdit:2065200] Orlic-Milacic, M, 2012-01-20
[InstanceEdit:2122950] Orlic-Milacic, M, 2012-02-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCDK8 phosphorylates xNICD1
output[Complex:1911412] RBPJ:SNW1 [nucleoplasm] [Homo sapiens]
[Complex:1604465] CDK8:CCNC [nucleoplasm] [Homo sapiens]
[CandidateSet:212357] MAML [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[CandidateSet:350078] PCAF [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2065162] p-xNICD1 [nucleoplasm] [Xenopus laevis]
releaseDate2012-03-13
reviewed[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
[Species:51320] Xenopus laevis
stableIdentifier[StableIdentifier:2158081] R-NUL-2065178.2
summation[Summation:2065197] TAD and PEST domains of NOTCH intracellular domain contain m...
(inferredFrom)[Reaction:1912391] NICD1 is phosphorylated by CDK8 [Homo sapiens]
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