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Details on Person FBXW7 mediates ubiquitination of phosphorylated NICD1

Class:Id	Reaction:2064883
_displayName	FBXW7 mediates ubiquitination of phosphorylated NICD1
_doRelease	TRUE
_timestamp	2012-03-01 11:28:22
authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
catalystActivity	[CatalystActivity:2064880] ubiquitin-protein transferase activity of p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2064882] Orlic-Milacic, M, 2012-01-19
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
input	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [Complex:2064852] p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Homo sapiens]
isChimeric	TRUE
literatureReference	[LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog [LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
modified	[InstanceEdit:2064889] Orlic-Milacic, M, 2012-01-19 [InstanceEdit:2122950] Orlic-Milacic, M, 2012-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FBXW7 mediates ubiquitination of phosphorylated NICD1
output	[Complex:2064879] Ub,p-NICD1 [nucleoplasm] [Homo sapiens] [Complex:1604469] FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:2158277] R-NUL-2064883.2
summation	[Summation:2064888] A recombinant mouse NICD1 was shown to be ubiquitinated upon...
(inferredFrom)	[Reaction:1852623] Ubiquitination of NICD1 by FBWX7 [Homo sapiens]
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No pathways have been reviewed or authored by FBXW7 mediates ubiquitination of phosphorylated NICD1 (2064883)