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Details on Person IRF3 is activated through a two-step phosphorylation in the ...
| Class:Id | Summation:2054083 |
|---|---|
| _displayName | IRF3 is activated through a two-step phosphorylation in the ... |
| _timestamp | 2012-01-12 22:39:24 |
| created | [InstanceEdit:2054082] Shamovsky, V, 2012-01-12 |
| text | IRF3 is activated through a two-step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKKi, requiring Ser386 and/or Ser385- site 1; and a cluster of serine/threonine residues between Ser396 and Ser405- site 2 [Panne et al 2007]. Phosphorylated residues at site 2 (Ser396 - Ser405) alleviate autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitate phosphorylation at site 1 (Ser385 or Ser386). Phosphorylation at site 1 is required for IRF3 dimerization. |
| (summation) | [Reaction:1606327] Phosphorylation and release of IRF3 [Homo sapiens] [Reaction:2396007] IRF3 is phosphorylated by TBK1 [Homo sapiens] |
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No pathways have been reviewed or authored by IRF3 is activated through a two-step phosphorylation in the ... (2054083)
