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Details on Person Direct recruitment of PI3K to p-KIT

Class:Id	Reaction:205262
_displayName	Direct recruitment of PI3K to p-KIT
_doRelease	TRUE
_timestamp	2011-09-09 09:02:56
authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:205198] Garapati, P V, 2007-12-10 09:55:47
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
input	[Complex:205310] p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] [Homo sapiens] [Complex:198379] PI3K alpha [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:1433318] Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant [LiteratureReference:1433283] Signal transduction via the stem cell factor receptor/c-Kit [LiteratureReference:1433408] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
modified	[InstanceEdit:1433337] Garapati, P V, 2011-07-11 [InstanceEdit:1470085] Garapati, P V, 2011-08-02 [InstanceEdit:1500885] Garapati, P V, 2011-08-22 [InstanceEdit:1524178] Garapati, P V, 2011-08-24 [InstanceEdit:1538125] Garapati, P V, 2011-08-26 [InstanceEdit:1562643] Garapati, P V, 2011-09-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Direct recruitment of PI3K to p-KIT
output	[Complex:205177] PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:205289] Autophosphorylation of KIT [Homo sapiens] [Reaction:205231] Dimerization of KIT upon SCF binding [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591362] R-HSA-205262.2
summation	[Summation:205272] The regulatory subunit (p85) of PI3K interacts directly with...
(hasEvent)	[Pathway:1433557] Signaling by SCF-KIT [Homo sapiens]
(normalReaction)	[Reaction:9670431] Phosphorylated KIT mutants bind PI3K [Homo sapiens]
(precedingEvent)	[Reaction:1433514] Synthesis of PIP3 from PIP2 by PI3K [Homo sapiens] [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 [Homo sapiens]
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No pathways have been reviewed or authored by Direct recruitment of PI3K to p-KIT (205262)