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Details on Person Recruitment of CBL to KIT

Class:Id	Reaction:205244
_displayName	Recruitment of CBL to KIT
_doRelease	TRUE
_timestamp	2011-09-09 09:04:46
authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:205198] Garapati, P V, 2007-12-10 09:55:47
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
input	[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [DefinedSet:1433400] Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:1433370] Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl [LiteratureReference:205273] The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit [LiteratureReference:912739] The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system [LiteratureReference:1562587] Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation
modified	[InstanceEdit:1433337] Garapati, P V, 2011-07-11 [InstanceEdit:1470008] Garapati, P V, 2011-08-01 [InstanceEdit:1470085] Garapati, P V, 2011-08-02 [InstanceEdit:1500885] Garapati, P V, 2011-08-22 [InstanceEdit:1524178] Garapati, P V, 2011-08-24 [InstanceEdit:1562643] Garapati, P V, 2011-09-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of CBL to KIT
output	[Complex:205200] CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1433506] Phosphorylation of APS [Homo sapiens] [Reaction:205319] Interaction of APS and p-KIT [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591395] R-HSA-205244.2
summation	[Summation:1433406] The phosphotyrosine residue in APS creates a putative bindin...
(hasEvent)	[Pathway:1433559] Regulation of KIT signaling [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment of CBL to KIT (205244)