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Details on Person Dimerization of KIT upon SCF binding

Class:Id	Reaction:205231
_displayName	Dimerization of KIT upon SCF binding
_doRelease	TRUE
_timestamp	2011-09-09 09:06:12
authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:205198] Garapati, P V, 2007-12-10 09:55:47
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
input	[EntityWithAccessionedSequence:197662] KIT [plasma membrane] [Homo sapiens] [Complex:205166] KIT:sSCF dimer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:1433309] Kit receptor dimerization is driven by bivalent binding of stem cell factor [LiteratureReference:1433294] Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer [LiteratureReference:205316] Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases [LiteratureReference:1433258] Human stem cell factor dimer forms a complex with two molecules of the extracellular domain of its receptor, Kit
modified	[InstanceEdit:1433337] Garapati, P V, 2011-07-11 [InstanceEdit:1433589] Garapati, P V, 2011-07-11 [InstanceEdit:1470085] Garapati, P V, 2011-08-02 [InstanceEdit:1500885] Garapati, P V, 2011-08-22 [InstanceEdit:1524178] Garapati, P V, 2011-08-24 [InstanceEdit:1564913] Garapati, P V, 2011-09-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of KIT upon SCF binding
output	[Complex:205208] KIT:sSCF dimer:KIT [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:205321] Interaction of KIT and sSCF [Homo sapiens] [Reaction:1433395] Dimerization of sSCF [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591426] R-HSA-205231.2
summation	[Summation:1433312] Binding of the SCF dimer to KIT rapidly triggers KIT dimeriz...
(hasEvent)	[Pathway:1433557] Signaling by SCF-KIT [Homo sapiens]
(precedingEvent)	[Reaction:205289] Autophosphorylation of KIT [Homo sapiens] [Reaction:9669893] KIT binds type I TKIs [Homo sapiens]
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