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Details on Person DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A

Class:IdReaction:204662
_displayNameDOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A
_doReleaseTRUE
_timestamp2016-10-17 17:42:31
authored[InstanceEdit:204654] Johansson, HE, 2007-11-28 23:26:30
catalystActivity[CatalystActivity:204618] deoxyhypusine monooxygenase activity of DOHH:Fe++ [cytosol]
catalystActivityReference[CatalystActivityReference:9644021] deoxyhypusine monooxygenase activity of DOHH:Fe++ [cytosol] Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A
compartment[Compartment:70101] cytosol
created[InstanceEdit:204657] D'Eustachio, P, 2007-11-28 23:36:29
edited[InstanceEdit:204639] D'Eustachio, P, 2007-11-28 23:33:46
input[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:73473] NADH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[DefinedSet:3149583] Dhp-K50-EIF5A [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:204666] Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].
[LiteratureReference:204643] Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A
[LiteratureReference:204752] Identification and characterization of eukaryotic initiation factor 5A-2
modified[InstanceEdit:204750] D'Eustachio, P, 2007-11-30 15:40:22
[InstanceEdit:211145] D'Eustachio, P, 2008-01-28 15:51:59
[InstanceEdit:213339] Gopinathrao, G, 2008-02-25 19:49:10
[InstanceEdit:215191] Gopinathrao, G, 2008-02-27 20:28:42
[InstanceEdit:3149581] Jupe, S, 2013-02-18
[InstanceEdit:8942445] D'Eustachio, Peter, 2016-10-14
[InstanceEdit:8942535] D'Eustachio, Peter, 2016-10-17
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A
EIF5A(Dhp) + O2 => EIF5A(Hyp)
output[DefinedSet:204658] Hyp-K50-EIF5A [cytosol] [Homo sapiens]
[SimpleEntity:29360] NAD+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:211144] Jassal, B, 2008-01-28 15:51:00
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358877] R-HSA-204662.4
summation[Summation:204616] Cytosolic deoxyhypusine hydroxylase (DOHH) complexed with Fe...
(hasEvent)[Pathway:204626] Hypusine synthesis from eIF5A-lysine [Homo sapiens]
(inferredFrom)[Reaction:1113238] EIF5A(Dhp) + O2 => EIF5A(Hyp) [Oryza sativa]
(orthologousEvent)[Reaction:1113238] EIF5A(Dhp) + O2 => EIF5A(Hyp) [Oryza sativa]
(updatedInstance)[_UpdateTracker:9782467] Update Tracker - [Reaction:204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A - v59:[addInput, addOutput, modifyText]
[_UpdateTracker:9787893] Update Tracker - [Reaction:204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A - v44:[add_removeInput]
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