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Details on Person CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain

Class:Id	Reaction:2046222
_displayName	CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain
_doRelease	TRUE
_timestamp	2025-03-14 09:01:55
authored	[InstanceEdit:2022912] Jassal, B, 2011-12-01
catalystActivity	[CatalystActivity:2046153] N-acetylglucosamine 6-O-sulfotransferase activity of CHST2,3,5,6 [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:2046181] Jassal, B, 2012-01-11
crossReference	[DatabaseIdentifier:9941347] RHEA:67857
edited	[InstanceEdit:2022912] Jassal, B, 2011-12-01
input	[DefinedSet:2046203] Keratan(4)-PG [Golgi lumen] [Homo sapiens] [SimpleEntity:741440] PAPS [Golgi lumen]
internalReviewed	[InstanceEdit:9941986] Stephan, Ralf, 2025-03-12
isChimeric	FALSE
literatureReference	[LiteratureReference:2161451] Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence [LiteratureReference:2161440] Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue [LiteratureReference:2161411] Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate
modified	[InstanceEdit:2161454] Jassal, B, 2012-03-14 [InstanceEdit:2161487] Jassal, B, 2012-03-14 [InstanceEdit:2162219] Jassal, B, 2012-03-16 [InstanceEdit:2247519] Jassal, B, 2012-05-14 [InstanceEdit:2428935] Jassal, B, 2012-08-09 [InstanceEdit:2457639] Jassal, B, 2012-08-27 [InstanceEdit:3465612] Jassal, Bijay, 2013-05-17 [InstanceEdit:5607069] Jassal, Bijay, 2014-07-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941068] Stephan, Ralf, 2025-03-07 [InstanceEdit:9941987] Stephan, Ralf, 2025-03-12 [InstanceEdit:9941990] Stephan, Ralf, 2025-03-12 [InstanceEdit:9942322] Stephan, Ralf, 2025-03-14
name	CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain Sulfation of GlcNAc residues on Keratan-PG forms KSPG
output	[SimpleEntity:742343] PAP [Golgi lumen] [DefinedSet:2046166] KSPG(1) [Golgi lumen] [Homo sapiens] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:2046285] ST3GAL1-4,6 optionally cap keratan chain [Homo sapiens] [Reaction:2046298] B4GALTs transfer Gal to a branch of keratan [Homo sapiens] [Reaction:741449] SLC35B2,3 exchange cytosolic PAPS with Golgi PAP [Homo sapiens] [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295183] R-HSA-2046222.3
structureModified	[InstanceEdit:9941068] Stephan, Ralf, 2025-03-07
summation	[Summation:2161467] Carbohydrate sulfotransferases 2, 3, 5 and 6 (CHST2, 3, 5 an...
(hasEvent)	[Pathway:2022854] Keratan sulfate biosynthesis [Homo sapiens]
(normalReaction)	[FailedReaction:3656269] Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG [Homo sapiens]
(precedingEvent)	[Reaction:2046175] CHST1 transfers sulfate to Gal on keratan chain [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786330] Update Tracker - [Reaction:2046222] CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG - v50:[modifyText] [_UpdateTracker:9953573] Update Tracker - [Reaction:2046222] CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain - v93:[modifyText, removeOutput]
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