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Details on Person DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A

Class:Id	Reaction:204617
_displayName	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A
_doRelease	TRUE
_timestamp	2019-04-19 14:56:19
authored	[InstanceEdit:204654] Johansson, HE, 2007-11-28 23:26:30
catalystActivity	[CatalystActivity:204646] deoxyhypusine synthase activity of DHPS tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644768] deoxyhypusine synthase activity of DHPS tetramer [cytosol] Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:204657] D'Eustachio, P, 2007-11-28 23:36:29
edited	[InstanceEdit:204639] D'Eustachio, P, 2007-11-28 23:33:46
input	[DefinedSet:3149583] Dhp-K50-EIF5A [cytosol] [Homo sapiens] [SimpleEntity:204628] 1,3-diaminopropane [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:204610] The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A) [LiteratureReference:8942446] Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase
modified	[InstanceEdit:211145] D'Eustachio, P, 2008-01-28 15:51:59 [InstanceEdit:213339] Gopinathrao, G, 2008-02-25 19:49:10 [InstanceEdit:3149581] Jupe, S, 2013-02-18 [InstanceEdit:8942445] D'Eustachio, Peter, 2016-10-14 [InstanceEdit:8942535] D'Eustachio, Peter, 2016-10-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9644771] D'Eustachio, Peter, 2019-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine
output	[DefinedSet:3149585] EIF5A [cytosol] [Homo sapiens] [SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:204635] SPM [cytosol]
releaseDate	2006-01-23
reverseReaction	[Reaction:204647] DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine [Homo sapiens] [Reaction:204617] DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A [Homo sapiens]
reviewed	[InstanceEdit:211144] Jassal, B, 2008-01-28 15:51:00
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359663] R-HSA-204617.4
summation	[Summation:204653] Cytosolic deoxyhypusine synthase (DHPS) tetramer catalyzes t...
(hasEvent)	[Pathway:204626] Hypusine synthesis from eIF5A-lysine [Homo sapiens]
(inferredFrom)	[Reaction:1113235] EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine [Oryza sativa]
(orthologousEvent)	[Reaction:1113235] EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine [Oryza sativa]
(reverseReaction)	[Reaction:204647] DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782364] Update Tracker - [Reaction:204617] DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A - v59:[addInput, addLiteratureReference, modifyText] [_UpdateTracker:9787595] Update Tracker - [Reaction:204617] DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A - v44:[add_removeInput, add_removeOutput]
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