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Details on Person Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

Class:Id	Reaction:2046088
_displayName	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
_doRelease	TRUE
_timestamp	2012-05-31 09:39:01
authored	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
catalystActivity	[CatalystActivity:548806] fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643484] fatty acid elongase activity of ELOVL1,2,3,5 [endoplasmic reticulum membrane] Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:2046086] Garapati, P V, 2012-01-11
edited	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
input	[SimpleEntity:2046052] SDA-CoA [endoplasmic reticulum lumen] [SimpleEntity:2046066] Malonyl-CoA [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2046008] Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids [LiteratureReference:2066751] Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
modified	[InstanceEdit:2066793] Garapati, P V, 2012-01-25 [InstanceEdit:2108997] Garapati, P V, 2012-02-13 [InstanceEdit:2152409] Garapati, P V, 2012-02-27 [InstanceEdit:2203420] Garapati, P V, 2012-04-20 [InstanceEdit:2248841] Garapati, P V, 2012-05-14 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
output	[SimpleEntity:2046051] ETA-CoA [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:162743] CoA-SH [endoplasmic reticulum lumen]
precedingEvent	[Reaction:2046084] Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA [Homo sapiens] [Reaction:2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294706] R-HSA-2046088.3
summation	[Summation:2045956] SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two ca...
(hasEvent)	[Pathway:2046106] alpha-linolenic acid (ALA) metabolism [Homo sapiens]
(precedingEvent)	[Reaction:2046089] Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA [Homo sapiens]
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