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Details on Person Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA

Class:Id	Reaction:2046084
_displayName	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
_doRelease	TRUE
_timestamp	2012-05-31 09:49:47
authored	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
catalystActivity	[CatalystActivity:2046082] acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2046086] Garapati, P V, 2012-01-11
edited	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
input	[SimpleEntity:2046062] ALA-CoA [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:194697] NADH [endoplasmic reticulum lumen] [SimpleEntity:194697] NADH [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:2046034] Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity [LiteratureReference:2045986] Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element [LiteratureReference:2046033] Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats [LiteratureReference:2045982] The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis [LiteratureReference:2066752] Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits
modified	[InstanceEdit:2066793] Garapati, P V, 2012-01-25 [InstanceEdit:2108997] Garapati, P V, 2012-02-13 [InstanceEdit:2152409] Garapati, P V, 2012-02-27 [InstanceEdit:2203420] Garapati, P V, 2012-04-20 [InstanceEdit:2248841] Garapati, P V, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA
output	[SimpleEntity:2046052] SDA-CoA [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:194653] NAD+ [endoplasmic reticulum lumen] [SimpleEntity:194653] NAD+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:2046085] Activation of alpha-linolenic acid to alpha-linolenoyl-CoA [Homo sapiens]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295140] R-HSA-2046084.2
summation	[Summation:2045930] Alpha-linoloyl-CoA is converted to Stearidonoyl-CoA (SDA, 6,...
(hasEvent)	[Pathway:2046106] alpha-linolenic acid (ALA) metabolism [Homo sapiens]
(precedingEvent)	[Reaction:2046088] Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA [Homo sapiens]
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