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Details on Person Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated...
| Class:Id | Summation:2045937 |
|---|---|
| _displayName | Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated... |
| _timestamp | 2012-01-11 13:32:44 |
| created | [InstanceEdit:2045929] Garapati, P V, 2012-01-11 |
| literatureReference | [LiteratureReference:2045940] Gamma linolenic acid: an antiinflammatory omega-6 fatty acid [LiteratureReference:2045924] Importance of dietary gamma-linolenic acid in human health and nutrition [Book:2045955] 1-893997-17-0 gamma-linolenic acid Antiatherogenic Potential of gamma Linolenic Acid Huang, YS |
| text | Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated to dihomo-gamma-linolenoyl-CoA (DGL-CoA; 8,11,14-20:3(n-6)) by the action of C18-PUFA-specific elongase 5 (ELOVL5). Two carbon atoms are added during this reaction. DGL-CoA later undergoes desaturation to form arachidonic acid (AA, 5,8,11,14-20:4(n-6)). Depending on the cell type, DGL-CoA can also be metabolized by cyclooxygenases and lipoxygenases to produce anti-inflammatory eicosanoids (prostaglandins of series 1 (PGE1) and 15-hydroxyeico- satrienoic acid (15-HETrE)). GLA and these two oxidative metabolites exert clinical effects in a variety of diseases, including suppression of chronic inflammation, vasodilation and lowering of blood pressure, inhibition of platelet aggregation and thrombosis. (Fan et al. 2001, Fan & Chapkin 1998, Kapoor & Huang. 2006) |
| (summation) | [Reaction:2046094] Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA [Homo sapiens] |
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No pathways have been reviewed or authored by Gamma-linolenoyl-CoA (6,9,12-20:3(n-6)) is rapidly elongated... (2045937)
