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Details on Person Arachidonyl-CoA undergoes a two-carbon chain elongation on t...

Class:IdSummation:2045934
_displayNameArachidonyl-CoA undergoes a two-carbon chain elongation on t...
_timestamp2012-01-27 16:19:22
created[InstanceEdit:2045929] Garapati, P V, 2012-01-11
literatureReference[LiteratureReference:2045926] Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors
[LiteratureReference:2045979] Elongation of long-chain fatty acids
modified[InstanceEdit:2066719] Garapati, P V, 2012-01-25
[InstanceEdit:2076702] Jupe, S, 2012-01-27
textArachidonyl-CoA undergoes a two-carbon chain elongation on the carboxyl end to form docosatetraenoyl-CoA (DTA-CoA/Adrenic acid/7,10,13,16-docosatetraenoic acid (7,10,13,16-22:4(n-6)). This reaction is catalyzed by the enzymes ELOVL5 or ELOVL2. Malanoyl-CoA provides the additional two carbons required for elongation. Docosatetraenoyl-CoA is further metabolized by cyclooxygenases (COX), lipoxygenases (LO) and cytochrome P450s (CYP450s) to dihomo (DH) eicosanoids (Kopf et al. 2010, Leonard et al. 2004).
(summation)[Reaction:2046083] Elongation of arachidonyl-CoA to docosatetraenoyl-CoA [Homo sapiens]
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