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Details on Person ROBO1 binds SLIT2

Class:Id	Reaction:204364
_displayName	ROBO1 binds SLIT2
_doRelease	TRUE
_timestamp	2017-11-17 16:24:12
authored	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:204366] de Bono, B, 2007-11-28 13:42:25
edited	[InstanceEdit:376175] Garapati, P V, 2008-09-05 06:02:05 [InstanceEdit:9009839] Orlic-Milacic, Marija, 2017-06-23
entityOnOtherCell	[EntityWithAccessionedSequence:375997] SLIT2 [extracellular region] [Homo sapiens]
input	[EntityWithAccessionedSequence:204361] ROBO1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:375997] SLIT2 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:375922] Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance [LiteratureReference:428397] Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching [LiteratureReference:204368] Movement through Slits: cellular migration via the Slit family
modified	[InstanceEdit:390381] Garapati, P V, 2009-01-30 00:02:15 [InstanceEdit:425198] Garapati, P V, 2009-06-03 [InstanceEdit:428538] Garapati, P V, 2009-07-06 [InstanceEdit:434971] Garapati, P V, 2009-09-04 [InstanceEdit:9009896] Orlic-Milacic, Marija, 2017-06-23 [InstanceEdit:9014808] Orlic-Milacic, Marija, 2017-08-04 [InstanceEdit:9014868] Orlic-Milacic, Marija, 2017-08-04 [InstanceEdit:9014892] Orlic-Milacic, Marija, 2017-08-04 [InstanceEdit:9029384] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ROBO1 binds SLIT2
output	[Complex:390371] ROBO1:SLIT2 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9010539] SLIT2 gene expression is stimulated by ISL1 [Homo sapiens] [Reaction:9010541] ISL1 binds the SLIT2 gene enhancer [Homo sapiens] [BlackBoxEvent:9011083] ROBO1 gene expression is inhibited by LHX2 [Homo sapiens] [Reaction:9011074] LHX2 binds to ROBO1 gene locus [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:434966] Kidd, T, 2009-08-18 [InstanceEdit:9014887] Jaworski, Alexander, 2017-07-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104547] R-HSA-204364.4
summation	[Summation:390357] SLIT2 ligand forms a complex with the ROBO1 receptor (Brose ...
(hasEvent)	[Pathway:376176] Signaling by ROBO receptors [Homo sapiens]
(precedingEvent)	[Reaction:376140] Ena/VASP proteins bind ROBO1:SLIT2 complex [Homo sapiens] [Reaction:376141] Interaction of ABL with ROBO1:SLIT2 [Homo sapiens] [Reaction:376145] SRGAP binds ROBO1:SLIT2 [Homo sapiens] [Reaction:428511] NCK binds ROBO1:SLIT2 [Homo sapiens] [Reaction:428536] ARHGAP39 (Vilse) binds ROBO1:SLIT2 [Homo sapiens] [Reaction:8985591] SLIT2-bound ROBO1 binds MYO9B [Homo sapiens] [Reaction:8986258] SLIT2:ROBO1 binds CXCR4 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780577] Update Tracker - [Reaction:204364] ROBO1 binds SLIT2 - v62:[add_removeInput, modifyText]
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No pathways have been reviewed or authored by ROBO1 binds SLIT2 (204364)