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Class:Id Reaction:203946 _displayName PDK isozymes phosphorylate PDHC subunit E1 _doRelease TRUE _timestamp 2024-04-24 07:29:27 authored [InstanceEdit:204185] Gopinathrao, G, 2007-11-26 20:29:38 catalystActivity [CatalystActivity:203942] pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isozyme dimers [mitochondrial matrix] catalystActivityReference [CatalystActivityReference:9643855] pyruvate dehydrogenase (acetyl-transferring) kinase activity of PDK isoforms [mitochondrial matrix] Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites compartment [Compartment:5460] mitochondrial matrix created [InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54 crossReference [DatabaseIdentifier:9861895] RHEA:23053 edited [InstanceEdit:203945] Gopinathrao, G, 2007-11-19 17:27:54 input [Complex:70070] PDH complex [mitochondrial matrix] [Homo sapiens] [SimpleEntity:113593] ATP [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix] literatureReference [LiteratureReference:204153] Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex [LiteratureReference:204164] Diversity of the pyruvate dehydrogenase kinase gene family in humans [LiteratureReference:450877] Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites [LiteratureReference:204152] Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase [LiteratureReference:450881] Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human [LiteratureReference:9861917] Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications [LiteratureReference:9861883] Orchestration of Mitochondrial Function and Remodeling by Post-Translational Modifications Provide Insight into Mechanisms of Viral Infection modified [InstanceEdit:204156] Gopinathrao, G, 2007-11-26 19:47:38 [InstanceEdit:204185] Gopinathrao, G, 2007-11-26 20:29:38 [InstanceEdit:204200] Gopinathrao, G, 2007-11-26 21:32:07 [InstanceEdit:204217] Gopinathrao, G, 2007-11-27 15:18:20 [InstanceEdit:209982] D'Eustachio, P, 2008-01-09 21:35:51 [InstanceEdit:210349] D'Eustachio, P, 2008-01-11 20:53:19 [InstanceEdit:212467] Gopinathrao, G, 2008-02-11 22:09:46 [InstanceEdit:213338] Gopinathrao, G, 2008-02-25 19:46:57 [InstanceEdit:215190] Gopinathrao, G, 2008-02-27 20:26:33 [InstanceEdit:450870] D'Eustachio, P, 2009-12-18 [InstanceEdit:5423008] Jassal, Bijay, 2014-05-08 [InstanceEdit:5423021] Jassal, Bijay, 2014-05-08 [InstanceEdit:5615674] Jassal, Bijay, 2014-07-28 [InstanceEdit:5615677] Jassal, Bijay, 2014-07-28 [InstanceEdit:9011478] Jassal, Bijay, 2017-06-30 [InstanceEdit:9011742] Jassal, Bijay, 2017-07-06 [InstanceEdit:9012031] Jassal, Bijay, 2017-07-10 [InstanceEdit:9026981] Jassal, Bijay, 2017-10-25 [InstanceEdit:9034402] Jassal, Bijay, 2018-01-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861887] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862189] Stephan, Ralf, 2024-02-23 [InstanceEdit:9862190] Stephan, Ralf, 2024-02-23 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24 name PDK isozymes phosphorylate PDHC subunit E1 negativePrecedingEvent [NegativePrecedingEvent:9908916] Futile Cycle: DLD dimer dehydrogenates dihydrolipoyl output [Complex:210342] p-lipo-PDH [mitochondrial matrix] [Homo sapiens] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars regulatedBy [PositiveRegulation:210332] Positive regulation by 'Ac-CoA [mitochondrial matrix]' [NegativeRegulation:210344] Negative regulation by 'PYR [mitochondrial matrix]' [PositiveRegulation:210348] Positive regulation by 'NADH [mitochondrial matrix]' [NegativeRegulation:9011392] Negative regulation by 'DCA:PDK2 [mitochondrial matrix]' releaseDate 2008-03-12 reviewed [InstanceEdit:210329] D'Eustachio, P, 2008-01-11 20:49:08 [InstanceEdit:9034401] James, Margaret, 2018-01-05 [InstanceEdit:9862191] Hill, David P, 2024-02-23 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:450856] D'Eustachio, P, 2009-12-18 [InstanceEdit:5423020] Jassal, Bijay, 2014-05-08 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:359867] R-HSA-203946.10 structureModified [InstanceEdit:9861887] Stephan, Ralf, 2024-02-21 [InstanceEdit:9862189] Stephan, Ralf, 2024-02-23 summation [Summation:204167] The mitochondrial pyruvate dehydrogenase (PDH) complex (lipo... [Summation:9026978] In the nucleus, cellular retinoic acid-binding protein 1 or ... (hasEvent) [Pathway:204174] Regulation of pyruvate dehydrogenase (PDH) complex [Homo sapiens] [Pathway:5362517] Signaling by Retinoic Acid [Homo sapiens] (precedingEvent) [Reaction:204169] PDP1,2 dephosphorylate p-lipo-PDH [Homo sapiens] (updatedInstance) [_UpdateTracker:9775953] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v78:[addSummation, modifyText] [_UpdateTracker:9780170] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v63:[modifyText, removeLiteratureReference] [_UpdateTracker:9780549] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v62:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9785557] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v51:[add_removeRegulator] [_UpdateTracker:9786626] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v49:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9791061] Update Tracker - [Reaction:203946] PDK isoforms phosphorylate lipo-PDH - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9864088] Update Tracker - [Reaction:203946] PDK isozymes phosphorylate PDHC subunit E1 - v88:[addLiteratureReference, addOutput, modifyText, removeRegulator]
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