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Details on Person Dimerization of FGFR4 mutants with enhanced kinase activity

Class:Id	Reaction:2038946
_displayName	Dimerization of FGFR4 mutants with enhanced kinase activity
_doRelease	TRUE
_timestamp	2014-12-03 20:54:31
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2038947] Rothfels, K, 2012-01-10
disease	[Disease:1500689] cancer [Disease:1614291] rhabdomyosarcoma
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654496] gain_of_function of FGFR4 enhanced kinase mutants [plasma membrane]
input	[CandidateSet:2038948] FGFR4 enhanced kinase mutants [plasma membrane] [Homo sapiens] [CandidateSet:2038948] FGFR4 enhanced kinase mutants [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
modified	[InstanceEdit:2046375] Rothfels, K, 2012-01-11 [InstanceEdit:2105613] Rothfels, K, 2012-02-10 [InstanceEdit:2123544] Rothfels, K, 2012-02-14 [InstanceEdit:2156382] Rothfels, K, 2012-02-28 [InstanceEdit:2248846] Rothfels, K, 2012-05-15 [InstanceEdit:2275109] Rothfels, K, 2012-05-25 [InstanceEdit:5654495] Rothfels, Karen, 2014-12-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of FGFR4 mutants with enhanced kinase activity
normalReaction	[Reaction:190265] FGFR4 binds to FGF [Homo sapiens]
output	[CandidateSet:2038942] FGFR4 enhanced kinase mutant dimers [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294920] R-HSA-2038946.2
summation	[Summation:2046364] FGFR4 is highly expressed in rhabdomyosarcoma (RMS) tissue, ...
(hasEvent)	[Pathway:1839128] FGFR4 mutant receptor activation [Homo sapiens]
(precedingEvent)	[Reaction:2038944] Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity [Homo sapiens] [Reaction:2046363] FGFR4 kinase mutants are inhibited by PD170734 [Homo sapiens]
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