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Details on Person FGFR4 enhanced kinase mutant dimers [plasma membrane]

Class:Id	CandidateSet:2038942
_displayName	FGFR4 enhanced kinase mutant dimers [plasma membrane]
_timestamp	2012-05-31 10:45:50
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2038943] Rothfels, K, 2012-01-10
disease	[Disease:1500689] cancer [Disease:1614291] rhabdomyosarcoma
hasCandidate	[Complex:2038930] FGFR4 N535D mutant dimer [plasma membrane] [Homo sapiens] [Complex:2038929] FGFR4 V550L mutant dimer [plasma membrane] [Homo sapiens]
hasMember	[Complex:2038928] FGFR4 N535K mutant dimer [plasma membrane] [Homo sapiens] [Complex:2038926] FGFR4 V550E mutant dimer [plasma membrane] [Homo sapiens]
name	FGFR4 enhanced kinase mutant dimers
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2298730] R-HSA-2038942.1
(diseaseEntity)	[EntityFunctionalStatus:5654468] gain_of_function of FGFR4 enhanced kinase mutant dimers [plasma membrane]
(hasComponent)	[Complex:2046360] FGFR4 mutant dimers with enhanced kinase activity:PD173074 [plasma membrane] [Homo sapiens]
(input)	[Reaction:2038944] Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity [Homo sapiens] [Reaction:2046363] FGFR4 kinase mutants are inhibited by PD170734 [Homo sapiens]
(output)	[Reaction:2038946] Dimerization of FGFR4 mutants with enhanced kinase activity [Homo sapiens]
(physicalEntity)	[CatalystActivity:2038941] protein tyrosine kinase activity of FGFR4 enhanced kinase mutant dimers [plasma membrane]
(updatedInstance)	[_UpdateTracker:9895686] Update Tracker - [CandidateSet:2038942] FGFR4 enhanced kinase mutant dimers [plasma membrane] - v59:[updateContainedMemberOrCandidate]
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No pathways have been reviewed or authored by FGFR4 enhanced kinase mutant dimers [plasma membrane] (2038942)