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Details on Person Pre-miRNA binds the RISC loading complex (RLC), a complex co...

Class:IdSummation:203846
_displayNamePre-miRNA binds the RISC loading complex (RLC), a complex co...
_timestamp2015-07-30 18:49:42
created[InstanceEdit:203816] Gopinathrao, G, 2007-11-18 23:55:40
literatureReference[LiteratureReference:203854] TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
[LiteratureReference:203825] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
[LiteratureReference:210566] Dicer is essential for mouse development
[LiteratureReference:210583] Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
[LiteratureReference:210567] A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
modified[InstanceEdit:210582] Gopinathrao, G, 2008-01-14 20:09:58
[InstanceEdit:211061] May, B, 2008-01-28 02:55:03
[InstanceEdit:426440] May, B, 2009-06-16
[InstanceEdit:432324] May, B, 2009-08-13
[InstanceEdit:432341] May, B, 2009-08-14
[InstanceEdit:432662] May, B, 2009-08-14
[InstanceEdit:629632] May, B, 2010-04-28
[InstanceEdit:2106631] May, B, 2012-02-10
[InstanceEdit:6789294] May, Bruce, 2015-07-29
[InstanceEdit:6789426] May, Bruce, 2015-07-30
textPre-miRNA binds the RISC loading complex (RLC), a complex containing DICER1, AGO2, and TARBP2 (TRBP). Alternative loading complexes contain AGO1, AGO3, or AGO4 rather than AGO2 and PRKRA (PACT) rather than TARBP2. The pre-miRNA substrate has an internal loop and a protruding 3' end created by cleavage by DROSHA:DGCR8. The DICER1:TARBP2 subcomplex or DICER1:PRKRA subcomplex recognizes this structure and the DICER1 component cleaves the pre-miRNA near the loop. The product is a double-stranded RNA of 21-25 nucleotides having 2-nucleotide protrusions at each 3' end. The products have 5' phosphates and 3' hydroxyl groups. Diffusion activity of TARBP2 and PRKRA along duplex RNA may enhance processing by DICER1.
(summation)[Reaction:203862] Dicer cleaves pre-miRNA to yield duplex miRNA [Homo sapiens]
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