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Details on Person Palmitoylation of eNOS

Class:Id	Reaction:203567
_displayName	Palmitoylation of eNOS
_doRelease	TRUE
_timestamp	2024-08-02 15:43:29
authored	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
catalystActivity	[CatalystActivity:203709] protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane]
catalystActivityReference	[CatalystActivityReference:9911155] protein-cysteine S-palmitoyltransferase activity of ZDHHC21 [Golgi membrane] Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:202104] Hemish, J, 2007-10-19 18:00:42
crossReference	[DatabaseIdentifier:9911164] RHEA:36684
input	[EntityWithAccessionedSequence:203687] MyrG-NOS3 [cytosol] [Homo sapiens] [SimpleEntity:200993] PALM-CoA [cytosol] [SimpleEntity:200993] PALM-CoA [cytosol]
internalReviewed	[InstanceEdit:9911325] D'Eustachio, Peter, 2024-05-28
literatureReference	[LiteratureReference:203720] Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase [LiteratureReference:203698] Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling [LiteratureReference:203760] Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae
modified	[InstanceEdit:203950] Gopinathrao, G, 2007-11-20 16:27:22 [InstanceEdit:204294] Gopinathrao, G, 2007-11-27 21:50:36 [InstanceEdit:212984] Gopinathrao, G, 2008-02-16 13:08:05 [InstanceEdit:213341] Gopinathrao, G, 2008-02-25 19:53:36 [InstanceEdit:215251] Gopinathrao, G, 2008-02-27 21:37:06 [InstanceEdit:215281] Gopinathrao, G, 2008-02-28 04:43:00 [InstanceEdit:215296] Gopinathrao, G, 2008-02-28 05:38:01 [InstanceEdit:215431] Gopinathrao, G, 2008-02-28 15:47:21 [InstanceEdit:215471] Gopinathrao, G, 2008-02-28 17:53:21 [InstanceEdit:534991] D'Eustachio, P, 2010-03-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24 [InstanceEdit:9911326] D'Eustachio, Peter, 2024-05-28 [InstanceEdit:9917335] D'Eustachio, Peter, 2024-08-02
name	Palmitoylation of eNOS hexadecanoyl-CoA + L-cysteinyl-(protein) => CoA + S-hexadecanoyl-L-cysteinyl-(protein)
output	[EntityWithAccessionedSequence:203769] 2xPalmC-MyrG-NOS3 [Golgi membrane] [Homo sapiens] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:203611] N-myristoylation of eNOS [Homo sapiens] [BlackBoxEvent:202132] depalmitoylated eNOS translocates from plasma membrane [Homo sapiens] [Reaction:203613] Depalmitoylation of eNOS [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-03-12
reviewed	[InstanceEdit:215470] Enikolopov, G, 2008-02-28 17:52:44 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359539] R-HSA-203567.3
structureModified	[InstanceEdit:9911167] D'Eustachio, Peter, 2024-05-24
summation	[Summation:203741] ZDHHC21, associated with the Golgi membrane, palmitoylates c...
(hasEvent)	[Pathway:203615] eNOS activation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:203700] eNOS translocation from Golgi to Caveolae [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790427] Update Tracker - [Reaction:203567] palmitoylation of eNOS - v33:[addInput] [_UpdateTracker:9919361] Update Tracker - [Reaction:203567] Palmitoylation of eNOS - v90:[modifyText, removeLiteratureReference, removeOutput]
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