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Details on Person Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity

Class:IdReaction:2033490
_displayNameAutocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
_doReleaseTRUE
_timestamp2015-05-07 19:53:58
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:2033451] protein tyrosine kinase activity of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2033491] Rothfels, K, 2012-01-09
disease[Disease:1500689] cancer
[Disease:2032940] bone development disease
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654452] gain_of_function of FGFR2 mutant dimers with enhanced kinase activity [plasma membrane]
input[CandidateSet:2033349] FGFR2 mutant dimers with enhanced kinase activity [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
[LiteratureReference:2033243] A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
[LiteratureReference:2033246] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis
[LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds
[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
modified[InstanceEdit:2060782] Rothfels, K, 2012-01-16
[InstanceEdit:2065937] Rothfels, K, 2012-01-24
[InstanceEdit:2105593] Rothfels, K, 2012-02-10
[InstanceEdit:2123523] Rothfels, K, 2012-02-14
[InstanceEdit:2156362] Rothfels, K, 2012-02-28
[InstanceEdit:2248846] Rothfels, K, 2012-05-15
[InstanceEdit:2275109] Rothfels, K, 2012-05-25
[InstanceEdit:5654451] Rothfels, Karen, 2014-12-03
[InstanceEdit:5691455] Rothfels, Karen, 2015-05-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
output[CandidateSet:2033348] Activated FGFR2 mutants with enhanced kinase activity [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294751] R-HSA-2033490.2
summation[Summation:2060754] Several missense mutations in the tyrosine kinase domain of ...
(hasEvent)[Pathway:2033519] Activated point mutants of FGFR2 [Homo sapiens]
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