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Details on Person Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding

Class:IdReaction:2033486
_displayNameAutocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
_doReleaseTRUE
_timestamp2015-05-07 19:54:07
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:2033453] protein tyrosine kinase activity of FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2033487] Rothfels, K, 2012-01-09
disease[Disease:1500689] cancer
[Disease:1614674] female reproductive endometrioid cancer
[Disease:1500575] ovarian cancer
[Disease:2032940] bone development disease
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654457] gain_of_function of FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:2065986] FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
modified[InstanceEdit:2060313] Rothfels, K, 2012-01-15
[InstanceEdit:2065861] Rothfels, K, 2012-01-24
[InstanceEdit:2065938] Rothfels, K, 2012-01-24
[InstanceEdit:2065995] Rothfels, K, 2012-01-25
[InstanceEdit:2105595] Rothfels, K, 2012-02-10
[InstanceEdit:2105675] Rothfels, K, 2012-02-10
[InstanceEdit:2123525] Rothfels, K, 2012-02-14
[InstanceEdit:2156364] Rothfels, K, 2012-02-28
[InstanceEdit:2248846] Rothfels, K, 2012-05-15
[InstanceEdit:2275109] Rothfels, K, 2012-05-25
[InstanceEdit:5654456] Rothfels, Karen, 2014-12-03
[InstanceEdit:5691457] Rothfels, Karen, 2015-05-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[Complex:2065989] Activated FGFR2c mutants with enhanced ligand-binding [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2294904] R-HSA-2033486.2
summation[Summation:2060295] After aberrantly dimerizing in response to mesenchymally exp...
(hasEvent)[Pathway:2033519] Activated point mutants of FGFR2 [Homo sapiens]
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