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Details on Person Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity

Class:IdReaction:2033485
_displayNameAutocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
_doReleaseTRUE
_timestamp2015-05-07 19:54:16
authored[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity[CatalystActivity:2033455] protein tyrosine kinase activity of FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:2033484] Rothfels, K, 2012-01-09
disease[Disease:1500689] cancer
[Disease:2032940] bone development disease
edited[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus[EntityFunctionalStatus:5654461] gain_of_function of FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane]
input[CandidateSet:2033383] FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:1637852] Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype
[LiteratureReference:2032934] Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II
[LiteratureReference:2032929] Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2032919] Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
modified[InstanceEdit:2065168] Rothfels, K, 2012-01-20
[InstanceEdit:2065184] Rothfels, K, 2012-01-20
[InstanceEdit:2065342] Rothfels, K, 2012-01-20
[InstanceEdit:2105597] Rothfels, K, 2012-02-10
[InstanceEdit:2123527] Rothfels, K, 2012-02-14
[InstanceEdit:2156366] Rothfels, K, 2012-02-28
[InstanceEdit:2248846] Rothfels, K, 2012-05-15
[InstanceEdit:2275109] Rothfels, K, 2012-05-25
[InstanceEdit:5654460] Rothfels, Karen, 2014-12-03
[InstanceEdit:5691459] Rothfels, Karen, 2015-05-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAutocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
output[CandidateSet:2033358] Activated FGFR3 mutants with enhanced kinase activity [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2295247] R-HSA-2033485.2
summation[Summation:2065183] Activated point mutants in the transmembrane and kinase doma...
(hasEvent)[Pathway:1839130] Signaling by activated point mutants of FGFR3 [Homo sapiens]
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