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Details on Person Dimerization of FGFR3 point mutants with enhanced kinase activity

Class:Id	Reaction:2033476
_displayName	Dimerization of FGFR3 point mutants with enhanced kinase activity
_doRelease	TRUE
_timestamp	2015-05-07 19:54:51
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2033477] Rothfels, K, 2012-01-09
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654492] gain_of_function of FGFR3 point mutants with enhanced kinase activity [plasma membrane]
input	[CandidateSet:2018770] FGFR3 point mutants with enhanced kinase activity [plasma membrane] [Homo sapiens] [CandidateSet:2018770] FGFR3 point mutants with enhanced kinase activity [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2032929] Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia [LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:2032934] Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:1637852] Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia [LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer [LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations [LiteratureReference:1637853] Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders [LiteratureReference:2032919] Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors [LiteratureReference:2032920] Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas [LiteratureReference:2065338] Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
modified	[InstanceEdit:2065167] Rothfels, K, 2012-01-20 [InstanceEdit:2065179] Rothfels, K, 2012-01-20 [InstanceEdit:2065343] Rothfels, K, 2012-01-20 [InstanceEdit:2105611] Rothfels, K, 2012-02-10 [InstanceEdit:2123542] Rothfels, K, 2012-02-14 [InstanceEdit:2156380] Rothfels, K, 2012-02-28 [InstanceEdit:2248846] Rothfels, K, 2012-05-15 [InstanceEdit:2275109] Rothfels, K, 2012-05-25 [InstanceEdit:5654491] Rothfels, Karen, 2014-12-03 [InstanceEdit:5691466] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of FGFR3 point mutants with enhanced kinase activity
output	[CandidateSet:2033383] FGFR3 point mutant dimers with enhanced kinase activity [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294682] R-HSA-2033476.2
summation	[Summation:2065320] Activating point mutations G380R, N540K and K650E/M/N/Q in F...
(hasEvent)	[Pathway:1839130] Signaling by activated point mutants of FGFR3 [Homo sapiens]
(precedingEvent)	[Reaction:2033485] Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity [Homo sapiens]
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