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Details on Person FGFR2b mutants bind an expanded range of ligands

Class:Id	Reaction:2033474
_displayName	FGFR2b mutants bind an expanded range of ligands
_doRelease	TRUE
_timestamp	2015-05-07 19:55:20
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2033475] Rothfels, K, 2012-01-09
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654518] gain_of_function of FGFR2b mutants with enhanced ligand binding [plasma membrane]
input	[SimpleEntity:190915] HS [extracellular region] [DefinedSet:2033371] FGFR2b mutants with enhanced ligand binding [plasma membrane] [Homo sapiens] [DefinedSet:2033371] FGFR2b mutants with enhanced ligand binding [plasma membrane] [Homo sapiens] [DefinedSet:2065925] FGFR2b mutant-binding FGFs [extracellular region] [Homo sapiens] [DefinedSet:2065925] FGFR2b mutant-binding FGFs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2012014] Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:1637876] Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome [LiteratureReference:2059901] Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome [LiteratureReference:2059900] Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity [LiteratureReference:2059894] Structural interactions of fibroblast growth factor receptor with its ligands [LiteratureReference:2059896] Structural basis for FGF receptor dimerization and activation [LiteratureReference:2059897] Receptor specificity of the fibroblast growth factor family [LiteratureReference:2029802] Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
modified	[InstanceEdit:2060318] Rothfels, K, 2012-01-15 [InstanceEdit:2065858] Rothfels, K, 2012-01-24 [InstanceEdit:2065922] Rothfels, K, 2012-01-24 [InstanceEdit:2065943] Rothfels, K, 2012-01-24 [InstanceEdit:2065960] Rothfels, K, 2012-01-24 [InstanceEdit:2105621] Rothfels, K, 2012-02-10 [InstanceEdit:2105675] Rothfels, K, 2012-02-10 [InstanceEdit:2123552] Rothfels, K, 2012-02-14 [InstanceEdit:2156390] Rothfels, K, 2012-02-28 [InstanceEdit:2248846] Rothfels, K, 2012-05-15 [InstanceEdit:2275109] Rothfels, K, 2012-05-25 [InstanceEdit:5654517] Rothfels, Karen, 2014-12-03 [InstanceEdit:5691471] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2b mutants bind an expanded range of ligands FGFR2b somatic mutants bind an expanded range of ligands
output	[Complex:2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294690] R-HSA-2033474.2
summation	[Summation:2060304] Apert sydrome is the most severe of the craniosynostosis syn...
(hasEvent)	[Pathway:2033519] Activated point mutants of FGFR2 [Homo sapiens]
(precedingEvent)	[Reaction:2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding [Homo sapiens]
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No pathways have been reviewed or authored by FGFR2b mutants bind an expanded range of ligands (2033474)