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Details on Person FGFR2c mutants bind an expanded range of ligands

Class:Id	Reaction:2033472
_displayName	FGFR2c mutants bind an expanded range of ligands
_doRelease	TRUE
_timestamp	2015-05-07 19:55:25
authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2033473] Rothfels, K, 2012-01-09
disease	[Disease:1500689] cancer [Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer [Disease:2032940] bone development disease
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654520] gain_of_function of FGFR2c mutants with enhanced ligand binding [plasma membrane]
input	[SimpleEntity:190915] HS [extracellular region] [CandidateSet:2033375] FGFR2c mutants with enhanced ligand binding [plasma membrane] [Homo sapiens] [CandidateSet:2033375] FGFR2c mutants with enhanced ligand binding [plasma membrane] [Homo sapiens] [DefinedSet:2065982] FGFR2c mutant binding FGFs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:2029802] Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities [LiteratureReference:2012014] Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome [LiteratureReference:1637876] Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome [LiteratureReference:2059901] Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome [LiteratureReference:2059894] Structural interactions of fibroblast growth factor receptor with its ligands
modified	[InstanceEdit:2060319] Rothfels, K, 2012-01-15 [InstanceEdit:2065855] Rothfels, K, 2012-01-24 [InstanceEdit:2065945] Rothfels, K, 2012-01-24 [InstanceEdit:2065994] Rothfels, K, 2012-01-25 [InstanceEdit:2105622] Rothfels, K, 2012-02-10 [InstanceEdit:2105675] Rothfels, K, 2012-02-10 [InstanceEdit:2123553] Rothfels, K, 2012-02-14 [InstanceEdit:2156391] Rothfels, K, 2012-02-28 [InstanceEdit:2248846] Rothfels, K, 2012-05-15 [InstanceEdit:2275109] Rothfels, K, 2012-05-25 [InstanceEdit:5654519] Rothfels, Karen, 2014-12-03 [InstanceEdit:5691472] Rothfels, Karen, 2015-05-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2c mutants bind an expanded range of ligands
output	[Complex:2065986] FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294884] R-HSA-2033472.2
summation	[Summation:2060302] Mutations in the highly conserved Pro-Ser dipeptide repeat o...
(hasEvent)	[Pathway:2033519] Activated point mutants of FGFR2 [Homo sapiens]
(precedingEvent)	[Reaction:2033486] Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding [Homo sapiens]
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No pathways have been reviewed or authored by FGFR2c mutants bind an expanded range of ligands (2033472)