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Details on Person Rothfels, K, 2012-01-09
| Class:Id | InstanceEdit:2033250 |
| _displayName | Rothfels, K, 2012-01-09 |
| _timestamp | 2012-01-09 03:51:07 |
| author | [Person:1226097] Rothfels, Karen |
| dateTime | 2012-01-09 08:51:03 |
| (created) | [LiteratureReference:2033240] Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation [LiteratureReference:2033241] Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice [LiteratureReference:2033242] Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma [LiteratureReference:2033243] A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases [LiteratureReference:2033244] The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells [LiteratureReference:2033245] High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies [LiteratureReference:2033246] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis [LiteratureReference:2033247] The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity [LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3 [LiteratureReference:2033249] Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients |
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No pathways have been reviewed or authored by Rothfels, K, 2012-01-09 (2033250)