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Details on Person p-6Y-FGFR3 K650M [plasma membrane]

Class:Id	EntityWithAccessionedSequence:2032959
_displayName	p-6Y-FGFR3 K650M [plasma membrane]
_timestamp	2014-11-20 17:31:38
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2032958] Rothfels, K, 2012-01-08
crossReference	[DatabaseIdentifier:2032956] COSMIC:COSV53391370 [DatabaseIdentifier:2032957] COSMIC:COSM85791
disease	[Disease:1493885] bladder carcinoma [Disease:2032940] bone development disease [Disease:1500689] cancer [Disease:1614388] multiple myeloma [Disease:1625209] thanatophoric dysplasia
endCoordinate	806
hasModifiedResidue	[ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ReplacedResidue:1614403] L-lysine 650 replaced with L-methionine
literatureReference	[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:1637853] Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders
modified	[InstanceEdit:2105029] Rothfels, K, 2012-02-09 [InstanceEdit:5649596] Rothfels, Karen, 2014-11-20
name	p-6Y-FGFR3 K650M
referenceEntity	[ReferenceGeneProduct:403340] UniProt:P22607 FGFR3 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2298719] R-HSA-2032959.1
startCoordinate	23
(hasComponent)	[Complex:2033334] Activated FGFR3 K650M mutant [plasma membrane] [Homo sapiens]
(inferredFrom)	[EntityWithAccessionedSequence:2033300] p-8Y-FGFR2 K660M [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9890745] Update Tracker - [EntityWithAccessionedSequence:2032959] p-6Y-FGFR3 K650M [plasma membrane] - v52:[modifyName]
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No pathways have been reviewed or authored by p-6Y-FGFR3 K650M [plasma membrane] (2032959)