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Details on Person Sel1l encodes an endoplasmic reticulum membrane protein that...
| Class:Id | Summation:2032752 |
|---|---|
| _displayName | Sel1l encodes an endoplasmic reticulum membrane protein that... |
| _timestamp | 2012-01-11 15:54:27 |
| created | [InstanceEdit:2032753] Orlic-Milacic, M, 2012-01-06 |
| modified | [InstanceEdit:2046133] Orlic-Milacic, M, 2012-01-11 |
| text | Sel1l encodes an endoplasmic reticulum membrane protein that is part of the ERAD (endoplasmic reticulum associated degradation) system, which performs quality control and triggers degradation of misfolded proteins (Francisco et al. 2010). Sel1l is a homolog of C. elegans sel-1, identified as a negative regulator of C. elegans Notch homolog lin-12 (Sundaram et al. 1993). Homozygous Sel1l mutant mouse embryos exhibit defects in differentiation of pancreatic cells and pancreas development that are rescued by pharmacological inhibition of Notch signaling (Li et al. 2010). |
| (summation) | [Reaction:2032750] Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum [Mus musculus] |
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No pathways have been reviewed or authored by Sel1l encodes an endoplasmic reticulum membrane protein that... (2032752)
